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Hypnotic doses of these barbiturates usually do not show up to considerably impair uterine action all through labor; complete anesthetic doses of barbiturates lower the pressure and frequency of uterine contractions; administration of sedative-hypnotic barbiturates on the mother for the duration of labor could end in respiratory despair in the newborn

In case the dose with the concomitant CYP3A4 inducer can't be minimized or discontinued, implant elimination can be important as well as affected individual should really then be addressed which has a buprenorphine dosage variety that allows dose adjustments. If a CYP3A4 inducer is discontinued within a affected person who continues to be stabilized on buprenorphine, keep track of the patient for overmedication.

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